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Simultaneously, studies using molecular biology detection and pharmacological intervention confirmed that heat stress triggers cPLA2 activation and increases the level of its metabolite arachidonic acid to participate in lipid peroxidation in the mouse heatstroke model, further promoting the occurrence of ferroptosis, thereby aggravating the progression of ALI after heat stress [48]

Compelling evidence has shown that oncogene-induced replication stress and dNTP exhaustion 30,31

10.1159/000365008 130 WuK.CastellanoD.TianQ.LuW

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