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Similarly, psilocybin, acting on multiple serotonin receptors, modulates ATP levels and mitochondrial respiration in neocortical cells via SIRT1-dependent mechanisms and the PGC-1-SIRT1 axis, with potential implications for mitochondrial biogenesis and long-term cellular adaptation [140,141,142]

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In a 2015 study, Leyens and colleagues concluded that between the years 2007 and 2015, 25 medicinal products had received accelerated approval from the FDA and 17 had received EMA conditional approval (25)