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PMI applied for both, but the FDA decided only to grant the exposure modification

It does not prove that e-cigarettes could not be of benefit if a smoker switches completely from tobacco cigarettes and uses them regularly, in the same way that FDA-approved nicotine replacement products are intended to be used. While it is generally agreed that e-cigarettes which deliver nicotine without many of the harmful products produced by burning tobacco reduce the health risks inherent in smoking cigarettes, few studies have directly investigated how useful they are in smoking cessation

How we should evaluate drugs and the harm they do There probably isnt a perfect way to evaluate and present all drug harms

extensive fatty change (EFC)