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[19] Accordingly, similar to the marketing efforts of e-cigarette companies, it is clear through promotional efforts by the tobacco companies selling oral nicotine products that they are incentivizing continued and uninterrupted use of their product in perpetuity and gaining significant appeal from youth who may not currently smoke, thereby potentially initiating or prolonging nicotine and tobacco dependence

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Particularly relevant to our current review, there is an enormous amount of literature that shows that smoking-derived nicotine exacerbates ischemic brain damage

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