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For COX4, homogenates were diluted in the same buffer, and heated at 100C for 10 minutes

Abstract Background Trace elements dyshomeostasis affects the physiological processes, metabolism, and immune function and leads to systemic and localised pathologies such as diabetes, cancer, and ocular degenerative diseases

Consistent to these findings, studies have shown that folic acid supplementation during pregnancy significantly reduces risk of NTDs and increases cognitive performance post-birth in humans [25,26,27]

In vitro models fail to recapitulate the complexity of the bone marrow microenvironment and overlook key pharmacokinetic factors such as renal excretion, potentially leading to inaccurate dose prediction