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In summary, the stability of urate crystals, the functional state of resident immune and stromal cells, and the integrity of the peripheral fibrous capsule interact in a finely balanced manner

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After correcting for multiple comparisons, there were significant increases in Tregs, S2 fibroblasts, pericytes, and endothelial cell subsets, with reductions in innate lymphoid cells (ILCs) and activated and memory CD4 + T cells in more severely inflamed segments (Fig