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We depleted haem from fetal bovine serum (FBS) following established methods 39,40 , which depleted the extracellular haem supply and confirmed that only haem was depleted, and not iron from FBS (Extended Data Fig

Biochimica et Biophysica Acta , (BBA)-Molecular Basis of Disease, 1866:165768

The endothelial glycocalyx is a critical component of cerebral vascular homeostasis, functioning as a dynamic barrier that regulates vascular permeability and neuroinflammatory signaling

Another important metalloporphyrin that inhibits HMOX1 activity is tin-protoporphyrin (SnPP), a molecule that was early evaluated as a potential therapy for hyperbilirubinemia in newborns, due to its capacity of inhibit the formation of bile pigments (6)