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Recent studies highlight the complex and dual role of GCN2 in cancer, given its involvement in ISR and UPR [16, 27, 28]

Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties

This procedure is preferred to the use of washed acid precipitated proteins as we noted that, after restoring neutral pH, the presence of a massive amount of denatured hemoglobin induces oxidation of the reducing agent used to detach GSH from GSSP, hampering a precise and accurate measurement of GSSP

To this end, reverse TH activity was measured in the absence and in presence of the membrane pore-forming peptide alamethicin that allows the membrane impermeable nucleotides to reach the binding sites of inwards-oriented TH