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This process occurs through a highly coordinated enzymatic cascade involving three steps: (1) activation of ubiquitin by the E1 ubiquitin-activating enzyme, (2) transfer of ubiquitin to the E2 ubiquitin-conjugating enzyme, and (3) substrate-specific ligation of ubiquitin by an E3 ubiquitin ligase [41]

(417) Jing, R

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