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C.-Y., Leow, M

Signaling pathways modulated by glutathione NRF2/KEAP1 antioxidant response: Oxidation or Sglutathionylation of Keap1 cysteines impairs Nrf2 ubiquitination, allowing Nrf2 stabilization, nuclear translocation, and induction of ARE-driven genes, including GCL subunits, the cystine/glutamate antiporter xCT, and GST isoformscreating a feed-forward elevation of GSH synthesis and conjugation capacity

The excretion of sulfate associated with the administration of methyl prednisolone is included to illustrate how a catabolic event can affect sulfur loss (Fig 6)

Whilst it's unlikely to dramatically lighten your skin tone on its own, glutathione can contribute to a brighter, more even complexion when used consistently as part of a well-rounded skincare routine