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Moreover, mitochondrial stress can lead to a significant loss of mitochondrial membrane potential, promoting apoptosis [100]

Gasdermin D (GSDMD) is cleaved by activated caspase-1, which results in the formation of membrane holes that promote pyroptosis (Liu et al

doi: 10.3389/fncel.2021.636176 Received 01 December 2020 Accepted 10 February 2021 Published 08 March 2021 Volume 15 - 2021 Edited by Jose Angel Morales-Garcia, Complutense University of Madrid, Spain Reviewed by Talita Glaser, University of So Paulo, Brazil