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(2005) A multicenter phase II trial of ZD6474, a vascular endothelial growth factor receptor-2 and epidermal growth factor receptor tyrosine kinase inhibitor, in patients with previously treated metastatic breast cancer

The transcriptomic divergence could simply reflect the difference between acute chemical shock and steady-state adaptation

For instance, Curcumin has been shown to covalently bind to the Cys151 residue of KEAP1, thereby stabilizing NRF2 and enhancing antioxidant effects

Acknowledgements The authors thank Conselho Nacional de Pesquisa e Tecnologia (CNPq) and Fundao de Amparo Pesquisa do Estado de So Paulo (FAPESP)