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"Section 529 Rare Pediatric Disease Priority Review Voucher Incentive Program, Public Law 112-144" (PDF)

Vitamin B3 (Niacin) Niacin, especially in high doses, can lead to gastrointestinal upset, including nausea and abdominal pain

Those which bind to the B12-IF complex, preventing uptake, those which bind to IF itself, preventing the binding with B12, and those which bind to parietal cells, preventing the production of IF to begin with