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La barrera hematoenceflica es una red de clulas endoteliales muy selectivas que decide qu molculas pueden ingresar al sistema nervioso central

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury

We observed that at early stages of tumour progression, NKX2-1 functions as a tumor suppressor, but later becomes an aggressive oncogene , contributing to cancer progression when nutrients such as serine and glycine become scarce