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Whether a specific transporter exists for glutathione import into the ER requires further investigation, but it is clear that the selective transport of GSH would provide one possible mechanism for the regulation of the [GSH]:[GSSG] ratio in the ER lumen

Cytoplasmic GSDMD is cleaved by Caspase-1, resulting in the release of its N-terminal domain from the autoinhibitory conformation binding to its C-terminal domain

Several clinical trials, including the Bone Marrow Derived Stem Cell Ophthalmology Treatment Study (SCOTS II), have explored the use of autologous bone marrow-derived stem cells (BMSC) for treating retinal and optic nerve conditions that cause irreversible vision loss

Cross N, Mahasreshti P (1997) Prostasome fraction of human seminal plasma prevents sperm from becoming acrosomally responsive to the agonist progesterone