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O 2 ions can also be produced during the operation of the enzyme xanthine oxidase and transformed into H 2 O 2 by a peroxisomal SOD

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In addition, HSV-1 has been reported to induce apoptosis in brainstems of mice infected with this virus, in which significant TUNEL-staining was observed at day 6 post-infection, although with low levels of detectable infectious virus, suggesting death of cells that were bystander to those infected with HSV-1 (Shaw et al., 2002)