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Accepted: August 23, 2016

A randomized, double-blind, placebo-controlled trial of deprenyl and thioctic acid in human immunodeficiency virus-associated cognitive impairment

The first line of the antioxidant defense system is the most powerful protective barrier against oxidative stress and involves enzymes with excellent catalytic activity, represented by superoxide radical-converting enzymes superoxide dismutases (SODs) , hydrogen peroxide-converting catalases (CAT) , and glutathione peroxidases (GPx) , enzymes that remove hydrogen peroxide and lipid hydroperoxides

However, resistance to anti-IV drugs is a major problem associated with these well-known therapeutics' agents