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The G allele of a second variant in the region, rs7096169 (intronic to BORCS7 and only in weak LD with rs12780116, r 2 = 0.18 in 1000G Europeans) increases smoking initiation and reduces expression of BORCS7 and AS3MT in eight brain tissues (including dorsolateral prefrontal cortex in the Brain xQTL and was the top BORCS7 eSNP in GTEx in the Cerebellar Hemisphere, Cerebellum, and Spinal cord cervical-C1)

Consensus so far: well-tolerated, low side-effect profile, real biological activity, individual response varies

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With consistent home care, professional interventions if needed, and quitting smoking, lips can regain a healthier, brighter appearance over time.The takeaway is simple: while smoking may have darkened your lips, the combination of science-backed care and lifestyle change can restore them