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The other disease that exhibits an indirect correlation with XO activity is non-alcoholic fatty liver disease (NAFLD)

Wu et al., 2020) [i.e., activation of the VEGFR2-Akt-eNOS signaling pathway without the need of other known ligands or shear stress (Stupnisek et al., 2015), and induce its own NO-release (Turkovic et al., 2004)