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Polyphenols: nutraceutical approach towards chronic fatigue Polyphenols are one of the most potent antioxidant phytochemicals, whose antioxidant effects are attributed to their ability to increase antioxidant defenses

Its activity is further influenced by co-factors, such as histone PARylation factor 1 (HPF1), which enhances the catalytic activity of PARP-1 and modifies substrate selectivity