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For example, pyruvate kinase muscle isoform 2 (PKM2) inactivation can both attenuate the glucose flux to PPP and enhance folate metabolism to mediate NADPH generation

In obesity, the spontaneous (197, 198) and stimulated (199) pulsatile patterns of GH secretion governed by the hypothalamus are blunted, and the accumulation of abdominal adiposity, particularly visceral adipose tissue mass, was found to be a stronger negative determinant of GH secretion than other factors including age, sex, or generalized obesity (200202)

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