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A 2024 Diabetes, Obesity and Metabolism study on a small-molecule NNMT inhibitor found it dose-dependently limited body weight and fat mass gains, improved oral glucose tolerance and insulin sensitivity, and suppressed hyperinsulinaemia in obese mice (PMID 39161060) [6]

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So in conjunction with a rapid medically supervised weight loss program or a body sculpting treatment (like CoolSculpting, Physiq, SculpSure) that breaks down fat cells, they do indeed help the liver process those fat cells out of the body