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Additionally, cytochrome P450 reductase facilitates ferroptosis through the lipid peroxidation process, which begins with the peroxidation of PUFAs via electron transfer, a mechanism closely associated with the lipid peroxidation cascade ( Notably, molecules that regulate lipid peroxidation are critical in ferroptosis, as dysfunction of these regulators profoundly influences cellular fate

Moreover, unlike wild-type recombinant TFG 1210 , TFG 1210 in which the PSAP motif was mutated to AAAA did not bind to the UEV domain (Fig

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