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In general, swelling caused by dependent edema, pregnancy, medications, and most diseases produces bilateral swelling (present in both feet or ankles ) and usually begins as a soft, puffy skin enlargement in the feet that spreads rapidly (often within hours) to the ankles

Always tell your provider about all medications and supplements you take, especially: Chemotherapy or radiation therapy

But the side effects that receive the least attention online are the ones that matter most to anyone considering it: significant lean muscle loss documented by DEXA scanning, dopamine suppression that can flatten mood and drive, and dosing decisions where the difference between 8 mg and 12 mg is roughly 1 percent more fat loss and approximately double the side effects

Hu, R., Ehlmann, B