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No receptor-mediated adverse events (e.g., cardiovascular effects, endocrine disruption) have been reported, consistent with NNMT's limited expression outside metabolic tissues

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However, the relative abundance of the genus Parasutterella , commonly decreased by HFD 61 , was increased in both the 5A-1MQ- and vehicle-treated mice switched from WD to LD, and the abundance of Parasutterella in all mice exhibited several correlations the EWAT metabolome

Individuals at risk include vegetarians, vegans, older adults, and those with gastrointestinal disorders that affect absorption