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This stands in marked contrast to what has happened in different situations in which clinical trials were designed according to predictive biomarkers such as, e.g., trastuzumab in HER2-positive breast cancer patients

But it was his job to ensure that the laws were satisfied and everyone had an opportunity to express their view and that the final product could withstand litigation as satisfying the NEPA requirements

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The methodological quality of the included studies, as assessed through the Jadad and NewcastleOttawa scales, varied from moderate to high, while the GRADE assessment indicated moderate certainty of evidence for serum vitamin B12 increase and low certainty for homocysteine reduction