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doi: ..10.1093/ndt/gfw082 [PubMed: 27190390] [CrossRef] 285

Glycolysis downregulation is a hallmark of HIV-1 latency and sensitizes infected cells to oxidative stress

The System Xc-on the cell membrane is an important part of keeping the homeostasis of the cellular antioxidant system, consisting of two parts: a light chain (xCT, transcribed by SLC7A11) and a heavy chain (4F2, transcribed by SLC3A2) (Xu et al., 2023a), which can exchange intracellular glutamate with extracellular cysteine (Parker et al., 2021)