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this effect is considered to play a crucial role in the pathogenesis of several psychiatric disorders such as depression, bipolar disorder and schizophrenia ( In recent years, dynamic disorders of mitochondria have been reported to result from mitochondrial dysfunction triggered by METH ( The regulation of mitochondrial fusion is primarily through mitofusin-1, mitofusin-2, and optic atrophy protein 1 (Opa1), whereas mitochondrial fission is regulated by mitochondrial fission 1 protein (Fis1) and dynamin-related protein 1 (Drp1) ( in vitro studies, Oxidative stress occurs primarily in mitochondria and leads to mitochondrial dysfunction by attacking mitochondria in the CNS (Xiong et al., 2017)

Management Specific management guidelines are listed here, with details below: Stop all protein intake Provide hydration with high caloric supplementation Correct biochemical abnormalities Eliminate toxic metabolites Treat precipitating factor(s) Provide cofactor supplementation Prevent associated sequelae 1

Wattacheril J, Sanyal AJ (2016) Lean NAFLD: an underrecognized outlier

Dunning KR, Russell DL, Robker RL