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Presentations of the StevensJohnson or toxic epidermal necrolysis types have occasionally been reported to stay within the irradiated field.50 The median time elapsing between radiotherapy and the appearance of the rash is 28 days, but longer intervals have been reported when there is no drug trigger.48 A subgroup of patients develop the so-called EMPACT syndrome (referring to erythema multiforme associated with phenytoin and cranial radiation therapy).51 In these cases, the disease has metastasized to the brain and concomitant treatment with phenytoin and cranial radiotherapy is required

In: IOP conference series: earth and environmental science 2019 Feb 1, vol 230., No

10.1016/j.bcp.2015.11.003 68