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Further research on GHK and skin wound closure in ischemic conditions suggested that over a period of 13 days, the peptide can lead to a notable decrease in wound area when compared to control or empty vehicle groups

Compared with unipolar depression, bipolar depressed subjects had significantly decreased connectivity between pgACC and amygdala and dorsomedial thalamus (150) Moreover, a separate group of investigators reported a more intense activation of ventral striatal, thalamic, hippocampal, amygdala, caudate nucleus/putamen, vmPFC, ventrolateral PFC, and ACC in bipolar depressed individuals compared with MDD and a healthy control group, especially in response to mildly and intensely fearful and sad, and mildly happy expressions (104)