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These hydroxyl radicals are able to oxidize lipids in the cell membrane

A more prudent and balanced approach to fortification with folic acid, or preferably a natural reduced folate, combined with vitamin B12 would potentially improve the benefits and reduce the harms, including epigenetic and transgenerational risks, associated with current public health policies

However, combination of gene and chelator therapy did not potentiate removal of copper, suggesting that a significant amount of the intracellular copper in WD hepatocytes may be stably bound to metallothionine

10.1038/s41467-017-01830-8 126 ShahrivarkevishahiA.HaggeL