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Studies have found that there are several ways to ultimately attenuate renal IRI by inhibiting the activation of the NLRP3 inflammasome, such as using hydrogen sulfide (H2S) [49], -hydroxybutyrate (-OHB) treatment [50], inhibiting mTORC1 with activated protein C (aPC) [51], and promoting zinc ion influx in renal TECs with transient receptor potential-6 (TRPC6) [52]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 139.Corcoran S.E., ONeill L.A