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Munc13-4 is essential for cytolytic granules fusion and is mutated in a form of familial hemophagocytic lymphohistiocytosis (FHL3)

(2012) www.sciencedaily.com From the article: We were surprised to observe a 50 percent reduction in testosterone in this pediatric study because these obese males were young and were not diabetic , says Paresh Dandona, MD, PhD, SUNY Distinguished Professor in the Department of Medicine, chief of the Division of Endocrinology, Diabetes and Metabolism in the UB medical school and first author on the study

doi: 10.1111/jpn.13725 109 WilliamsERumseyRPowersH

Our cases report confirmed findings from studies that link HLA-B*58:01 and allopurinol-induced SJS/TEN conducted in other Asian countries, including Thailand and Vietnam ( HLA-B*58:01 in Javanese ethnics is around 6%, which is comparable to other Southeast Asian populations ( HLA-B*58:01 allele is quite frequent among the study participants ( Our study supports findings from other studies that HLA-B*58:01 can potentially be used as a pharmacogenetic marker for allopurinol-induced SCARs ( HLA-B*58:01 among population in the region ( HLA-B*58:01 and SCARs and provide evidence for policymaking on genetic screening test in Indonesia is warranted