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In SH-SY5Y/MYCN cells, (M+D)/2 had no effect on cell death, while (M+D+V)/3 increased toxicity at 48 and 72 hours ( Figure 4A )

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The Melbourne-based company, which does not manufacture the drug, claims it is a potential treatment for cartilage and muscle damage and even osteoarthritis, though there is absolutely no clinical evidence of that

Furthermore, given that the patients with high pre-treatment CD38 levels on MM cells have a better response to Daratumumab monotherapy, high CD38 expression on MM cells seems satisfactory to maximize the clinical efficacy such as the combination treatment of CD16F158V CD38 low NK cells and Daratumumab [120]