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In the following section, we will take a closer look at tesamorelin

P-glycoprotein can efflux small molecule tyrosine kinase inhibitors (TKIs) used as chemotherapy agents, such as dasatinib, imatinib, vandetanib and nintendanib (17), as well as the standard GBM chemotherapy agent, TMZ (18)

This restricts blood flow, raises blood pressure, and impairs organ function 71 72

The molecule was first identified and studied by the Sikiric research group in Croatia starting in the early 1990s, and the bulk of the preclinical evidence base comes from more than three decades of rat and rodent studies showing consistent tissue-repair, anti-inflammatory, and gastroprotective effects