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For adverse events was same, the same article (Yaikwawong et al., 2024) was not included in the statistics, then the result changed from OR = 0.03, CI 95%: 0.03, 0.09 I 2 = 64% to OR = 0.01, 95% CI: 0.03, 0.06 I 2 = 23%

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In brief, inhibition of TrxR augments the susceptibility of tumor cells to oxidative stress, bolsters the selective eradication of cancerous cells, and instigates the cascade of apoptosis, which has received widespread attention in recent years making TrxR a potential target for cancer therapy (191, 192)