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Dante, who imagined the mountain of Purgatory as being a solitary island in the centre of the watery hemisphere in the antipodes of Jerusalem, mentions the mouth of the Ganges more than once as being the eastern point of the astronomical horizon, common to both hemispheres, the only difference being that in Jerusalems hemisphere, at that point, the sun is seen to rise while in the opposite hemisphere, at the same point, it is seen to set (Purgatory, II, 5 Purgatory XXVII, 4 Paradise, XI, 51)

The guidelines are critical for maintaining high standards in medical research while providing comprehensive protection for human participants