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Matsubara H, Sugaya T, Murasawa S, Nozawa Y, Mori Y, Masaki H, Maruyama K, Tsutumi Y, Shibasaki Y, Moriguchi Y, Tanaka Y, Isawaka T, Inada M

Tirzepatide, on the other hand, is a newer medication that also targets both GLP-1 and GIP receptors but has gained significant attention due to its impressive results in clinical trials and recent FDA approval for type 2 diabetes treatment

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In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation