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Known small molecules that bind to and modulate target genes and/or gene products, as well as information about the biological activities and pathways affected, are readily available from publicly available databases (e.g., drug bank, PharmGKB, MedChemExpress, and seleckchem)

High levels of circulating IGF1 and certain genetic polymorphisms of IGF1 and IGFBP3 are associated with an increased risk of several common cancers

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