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The pathogenesis of PD-related sleep disorders is not fully understood, but it is believed to involve changes in neural anatomy, neuron loss, neurotransmitter alterations, genetics, environmental factors, and psychological influences (5)

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In addition, withaferin A (WA), a natural ferroptosis inducer in NB, activates Kelch-like ECH-associated protein 1 to activate the nuclear factor-like 2 pathway and produces increased intracellular unstable Fe(II) levels after heme oxygenase-1 is excessively activated, inducing ferroptosis or inactivating GPX4 (109)