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Specifically, these commenters recommended CMS treat the benchmark quarter CPI-U in the same manner as CMS' approach for subsequently approved drugs

For this review, we will use biochemical signaling to refer to the binding of vascular endothelial growth factor (VEGF) to VEGF receptor 2 (VEGFR-2), while biomechanical signaling will refer to VEGFR-2 activation or downstream signaling induced by non-ligand binding cues