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10.1056/NEJMoa003417 158 VeseliB

These experiments highlight the complex and highly dynamic redox landscape of the cell, where individual redox couples, even within a single subcellular compartment, often do not equilibrate with each other in vivo

Additionally, the CFAX12 lung-on-chip platform is the only system to integrate biomechanical stretch, simulating breathing-like forces, which significantly influence cellular responses to cigarette smoke exposure

3D, lower right), likely due to the predominant formation of the hyperoxidized form as observed for GPx7 WT in the presence of 200 M H 2 O 2 and 10 M reduced PDI (Fig