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Accessed 3 July 2024

To enhance translational relevance, recent innovations have integrated PDOs with autologous immune cell or stromal co-culture, and in vivo models such as PDO-derived xenografts (PDXs) and liver metastasis organoid models have been applied for validation

Individual results vary, and DSIP is not appropriate for everyone: People with chronic insomnia that has not responded adequately to behavioral or conventional pharmacological interventions Shift workers or frequent travelers are dealing with circadian rhythm disruption Individuals experiencing stress-related sleep disturbances and elevated cortisol patterns Athletes and active individuals seeking to optimize recovery through improved sleep quality Older adults experiencing age-related changes in sleep architecture and hormone secretion People who have experienced side effects from traditional sleep medications and are seeking non-sedating alternatives Individuals managing chronic pain conditions that interfere with restorative sleep Struggling with sleep and recovery

Barocas VH, Balachandran RK