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However, there was no overall improvement in depression symptoms, pain scores or in the results of a 12-item short form health survey

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Convenience, Frequency, And Cost Injections Require syringes, safe disposal, and usually medical supervision Often weekly or monthly, depending on protocol Costs can add up with repeated clinic visits Nasal spray Takes a few seconds, wherever you are Easy to build into a daily routine No sharps, no office visit, and generally lower ongoing cost For many busy professionals, athletes, and biohackers, nasal sprays offer most of the benefits of injections with a lower barrier to consistent use

We are presenting it as the clinical pattern we have seen, with the appropriate caveats that clinical observation is subject to selection bias and confounding