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Total and ultrafiltrate platinum from PIPAC at dose of 120 mg/m 2 were 3.8% and 10.2% respectively of that reported for 2-h IV of single-dose oxaliplatin at 130 mg/m 2 , not likely to induce significant systemic adverse events

The authors observed a 50% increase in MDA, a reduction in SOD, GPx4, and Xc- protein expression, and a 60% increase in ACSL4 levels

In order to selectively inhibit transcription, the repressor protein can mask the transcription activation domain, block the interaction of the activator with other components of the transcription mechanism, or replace the activator from the DNA