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Larger Phase IIb trial: development terminated In 2007, a larger 24-week trial with 536 subjects failed to demonstrate weight loss significant enough to support pharmaceutical viability

Briefly, the PPI session started with a 5-min habituation period, in which only a background noise (BN) of 7273 dB was presented, followed by 5 consecutive startle trials, which were excluded from the statistical analysis, and 9 different trial types were repeated 10 times in random order and with an intertrial interval of 25 s on average

What worked

Jesse Goodman of Georgetown University, a former FDA vaccine chief, said it "makes sense" to update the vaccines to target new variants circulating