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doi: 10.2174/187231207780363633 45 HamiltonLEOkoRMiranda-VizueteASutovskyP

until then, its use should remain confined to established metabolic indications

Pretreatment of animals with naloxone (2 mg/kg) abolished the antitussive effect of thymoquinone and codeine indicating that thymoquinone exerts antitussive activity by its anti-inflammatory, bronchodilatory effects mediated probably through opioid receptors [61]