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The authors of this experiment stated that this activity of Epitalon can explain most of the geroprotective effects of this compound [33]

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In tolerance experiments with high doses of LPS-induced sepsis, changes in histone H3K4me3, H3K27me2, and histone methyltransferase complexes (102, 151, 152) can downregulate the genes encoding inflammatory factors while upregulating the anti-inflammatory factor genes (153, 154)