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UDCA treatment drives a marked increase of Lithocholic acid (LCA) flux through the large intestine, while Gly-b-MCA treatment cause gut unconjugated MCA enrichment and reduced gut cytotoxic LCA abundance

The response by Robert Dickey of the FDA (Dickey, 2012), argued that the conservative approach used by FDA likely overestimated actual risk, including by assuming a 5-year consumption period of the contaminated seafood

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