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Increased energy levels: Vitamins like B12 and magnesium work to combat fatigue and improve mental clarity

Clinical trials have utilized doses ranging from 1 mg per day up to 30 mg per day in divided doses for various administration routes

5 Heurteaux et al., Nature Neuroscience (2006)TREK-1 knockout produces a depression-resistant phenotype, establishing TREK-1 as an antidepressant target

However some people may have symptoms of vitamin B12 deficiency despite normal vitamin B12 blood test results, or may have low blood levels despite having no symptoms